How often should I replace the filters in my HPA5100?
The Pre-Filter should be replaced every 3 months, and the HEPA Filter should be replaced every 12 months. These replacement intervals are guidelines only, as high concentrations of particles like dust, pet dander, and smoke can reduce filter performance more quickly. (Page 7)
From the official Honeywell Hpa5100 Air Purifier manual, page 7
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