How often should I replace the batteries in my TH6220D?

Batteries should be replaced once a year, or before leaving home for more than a month. You should also install fresh batteries immediately when the REPLACE BATTERY warning begins flashing on the display, which appears approximately two months before the batteries are fully depleted. (Page 17)

From the official Honeywell T6220D Programmable Thermostat manual, page 17

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