How do I permanently hold the temperature and turn off the program schedule?

Press the HOLD button to permanently adjust the temperature and override all programmed time periods. The thermostat will maintain whatever temperature you set 24 hours a day until you manually change it or press RUN SCHEDULE to cancel the Hold feature and resume the programmed schedule.

From the official Honeywell TH6220D1028 Thermostat manual, page 13

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