How do I set the time and day on my Honeywell thermostat?

Press the SET CLOCK/DAY/SCHEDULE button, then press the up or down arrow to set the clock time. Next, press the SET DAY button and press the up or down arrow to select the day of the week. Finally, press DONE to save and exit. Setting the time and day is required for proper thermostat operation.

From the official Honeywell TH6220D1028 Thermostat manual, page 6

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