Can unauthorized modifications affect the operation of my thermostat?

Yes, according to FCC regulations (Part 15.21), changes or modifications not expressly approved by the party responsible for compliance could void the user's authority to operate the equipment. It is important not to make any unauthorized modifications to the thermostat. (Page 4)

From the official Honeywell TH6220WF2006 Thermostat manual, page 4

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