Does the TH8320U thermostat support zone valve systems?

Yes, the TH8320U supports heat only systems using two-wire configurations, including power to open and close zone valves (Series 20) and normally open zone valves. This makes it compatible with a variety of hydronic heating setups. (Page 1)

From the official Honeywell Th8320U1008 Thermostat manual, page 1

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