Can I customize the side buttons on the Signature M650?

Yes, the side buttons are customizable using Logi Options+ software. Logi Options+ is available on Windows 10 and macOS 10.15 or later. Common customizations include back/forward or copy/paste functions. (Page 1)

From the official Logitech Logitech Signature M650 Wireless Mouse User manual, page 1

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