What should I do if I see the E2 error code?

The E2 error appears when you move or talk during measurement, the arm cuff doesn't inflate sufficiently, or your systolic pressure is above 210 mmHg. To fix it, remain still and don't talk during measurement. If E2 appears repeatedly, manually inflate the arm cuff until the systolic pressure is 30 to 40 mmHg above your previous readings. (Page 36)

From the official Omron BP7250 Blood Pressure Monitor manual, page 36

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