When should I stop using the ePod 2 and seek medical advice?

You should immediately stop use and seek medical advice if you experience an irregular heartbeat, allergic reactions such as rash, itching, or swelling of the tongue, mouth, or throat, feeling faint, nausea, headache, or any other unusual or adverse effect. You should also not use the device if it shows signs of damage. (Pages 2, 16)

From the official Vuse Epod 2 manual, page 2

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