How do I set the time and day on my Honeywell FocusPro TH6220D thermostat?

Press SET CLOCK/DAY/SCHEDULE, then adjust the clock time by pressing s or t. Next, press SET DAY to select the current day of the week (s for Sunday, t for Monday). Press DONE to save and exit the settings.

From the official Honeywell Focuspro Th6220d manual, page 6

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