How often should I replace my filters?
The Pre-Filter and Enhanced Odor & VOC filters should be replaced every 3 months, while HEPA filters should be replaced every 12 months. However, these are guidelines only and individual home conditions may vary, so filters should be checked periodically. High concentrations of particles such as dust, pet dander, and smoke will reduce the useful performance of the filters. (Page 7)
From the official Honeywell Hpa5100 Air Purifier manual, page 7
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